Alleles for which the sequence change is known are listed in boldface.
The following phenotypes have been observed in unc-77:
| Phenotype | Entities Affected | Supporting Evidence |
|---|---|---|
| nose movement variant | Allele: e625
details
| |
| head bend angle variant | Allele: gk9
details
| |
| exaggerated body bends | Allele: e625 Curator: Karen Yook
Ease of scoring: Es2 difficult to score Person evidence: Jonathan Hodgkin Remark: irregular loopy movement both forward and reverse; slight movement abnormality in e625/+ Semi dominant: Person_evidence; Curator_confirmed details
| |
| forward point velocity decreased | Allele: gk9
details
| |
| coiler | Allele: hp102 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Mutants showed semi-dominant, uncoordinated, and exaggerated body bends during either spontaneous or stimulated locomotion. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| short | Allele: gk9
details
| |
| short | Allele: e625
details
| |
| thin | Allele: e625 Curator: Karen Yook; Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013 Person evidence: Jonathan Hodgkin details
| |
| tail bend angle decreased | Allele: gk9
details
| |
| coiling frequency increased | Allele: e625
details
| |
| endogenous synaptic event frequency reduced | Allele: e625 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Some animals displayed a normal frequency of mPSC while others had no mPSC at all. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| body posture wavelength decreased | Allele: gk9
details
| |
| protruding vulva | Allele: e625
details
| |
| roaming reduced | Allele: e625
details
| |
| forward locomotion variant | Allele: e625
details
| |
| evoked postsynaptic current variant | Allele: hp102 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: No ePSC could be evoked. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| amplitude of sinusoidal movement variant | Allele: gk9
details
| |
| constitutive egg laying | Allele: e625 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| synapse morphology variant | Allele: hp102 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Animals exhibited unusually large HSN synapses. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| pausing decreased | Allele: e625
details
| |
| backward point velocity decreased | Allele: gk9
details
| |
| body posture amplitude decreased | Allele: gk9
details
| |
| backing decreased | Allele: gk9
details
| |
| body posture amplitude increased | Allele: e625
details
| |
| endogenous synaptic event frequency reduced | Allele: hp102 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Some animals displayed a normal frequency of mPSC while others had no mPSC at all. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| thin | Allele: gk9
details
| |
| locomotion variant | Allele: | |
| synapse morphology variant | Allele: e625 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Animals exhibited unusually large HSN synapses. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| constitutive egg laying | Allele: hp102 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| path curvature variant | Allele: e625
details
| |
| pausing variant | Allele: gk9
details
| |
| transgene subcellular localization variant | Allele: hp102 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Animals exhibited abnormal active zone marker distribution. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| body posture wavelength decreased | Allele: e625
details
| |
| path curvature increased | Allele: gk9
details
| |
| backward point velocity variant | Allele: e625
details
| |
| frequency of body bend variant | Allele: e625
details
| |
| forward point velocity variant | Allele: e625
details
| |
| turning frequency variant | Allele: e625
details
| |
| tail bend angle variant | Allele: e625
details
| |
| forward locomotion decreased | Allele: gk9
details
| |
| amplitude of sinusoidal movement increased | Allele: e625
details
| |
| frequency of body bend variant | Allele: gk9
details
| |
| coiling frequency decreased | Allele: gk9
details
| |
| head bend angle variant | Allele: e625
details
| |
| turning frequency increased | Allele: gk9
details
| |
| coiler | Allele: e625 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Mutants showed semi-dominant, uncoordinated, and exaggerated body bends during either spontaneous or stimulated locomotion. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| nose movement decreased | Allele: gk9
details
| |
| evoked postsynaptic current variant | Allele: e625 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: No ePSC could be evoked. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| backward locomotion variant | Allele: e625
details
| |
| transgene subcellular localization variant | Allele: e625 Curator: Karen Yook
Paper evidence: Yeh E et al., 2008 Remark: Animals exhibited abnormal active zone marker distribution. Semi dominant: Curator_confirmed; Paper_evidence Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence details
| |
| protein degradation variant | RNAi: WBRNAi00090483 Genotype: ccIs55 [unc-54::lacZ]; daf-18(e1375)
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011 Remark: The daf-18(e1375) mutation failed to suppress the RNAi-induced increase in muscle protein degradation, as determined by LacZ staining, suggesting that this increase in degradation is not dependent on the daf-18 gene or the Insulin-like signaling pathway, of which daf-18 is a part. details
| |
| protein degradation variant | RNAi: WBRNAi00090389 Genotype: ccIs55 [unc-54::lacZ]; unc-51(e369)
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011 Remark: The unc-51(e369) mutation failed to suppress the RNAi-induced increased in muscle protein degradation, as determined by LacZ staining, suggesting that this increase in degradation is not dependent on the unc-51 gene or the Autophagy pathway, of which unc-51 is a part. details
| |
| protein degradation variant | RNAi: WBRNAi00090436 Genotype: ccIs55 [unc-54::lacZ]; mpk-1(n2521)
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011 Remark: The mpk-1(n2521) mutation failed to suppress the RNAi-induced increased in muscle protein degradation, as determined by LacZ staining, suggesting that this increase in degradation is not dependent on the mpk-1 gene or the Fibroblast Growth Factor pathway, of which mpk-1 is a part. details
| |
| protein degradation variant | RNAi: WBRNAi00089961 Genotype: ccIs55 [unc-54::lacZ]
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011 Remark: RNAi was observed to significantly reduce cytosolic protein levels in body wall muscles, as determined by reduced LacZ staining compared to controls. This affect was observed after chronic RNAi exposure (RNAi continuously for two generations), as well as after acute exposure to RNAi only during adulthood. details
| |
| protein degradation variant | RNAi: WBRNAi00090530 Affected by molecule: MG132
Genotype: ccIs55 [unc-54::lacZ] Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011 Remark: The proteasome inhibitor MG132 failed to suppress the RNAi-induced increase in muscle protein degradation, as determined by LacZ staining, suggesting that this increase in degradation is not dependent on the proteasome. details
| |
| mitochondria morphology variant | anatomy-term: body wall muscle cell, abnormal | RNAi: WBRNAi00090279 Genotype: ccIs4251 [Pmyo-3::MitGFP, Pmyo-3::NLS::GFP-lacZ]
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011 Remark: RNAi was observed to significantly perturb mitochondrial morphology in body wall muscles, as determined by observation of a muscle-specific fluorescent mitochondrial reporter. This affect was observed after chronic RNAi exposure (RNAi continuously for two generations), as well as after acute exposure to RNAi only during adulthood. details
|
The following phenotypes are indirectly caused or affected by some perturbation of unc-77 in the context of a genetic interaction :
Notice a missing phenotype? Please let us know via ourPhenotype Form