Phenotypes:

Alleles for which the sequence change is known are listed in boldface.

The following phenotypes have been observed in egl-19:

Phenotype Entities Affected Supporting Evidence
paralyzed arrested elongation two foldAllele:
n2368ad979
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Recessive:
Remark: recessive Pat
details
drug resistantAllele:
tr84
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr77
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr74
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
eating variantAllele:
n2368
Curator: Karen Yook
Ease of scoring: Es3 easy to score
Person evidence: Jonathan Hodgkin
Remark: Eat. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed
details
constitutive egg layingAllele:
tr89
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
shortAllele:
drug resistantAllele:
tr75
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
shortAllele:
tr86
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
details
thinAllele:
shortAllele:
backward point velocity variantAllele:
spicules protrude Allele:
tr76
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
constitutive egg layingAllele:
tr92
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr74
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals continued to retain eggs after treatment with the dihydropyridine (DHP) analog nemadipine compared with control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
terminal bulb relaxation variant Allele:
ad695
Curator: Jolene S. Fernandes
Paper evidence: Avery L, 1993
Semi dominant: Curator_confirmed; Paper_evidence
details
multipolar neuronanatomy-term: ALM, abnormalAllele:
n2368
Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, where a short process extends from the posterior side of the ALM cell body, whereas, in wild-type, a single process extends from the anterior side of the ALM cell body.
details
drug resistantAllele:
tr79
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr139
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
sluggishAllele:
n582
details
egg laying serotonin resistantAllele:
n582
Curator: Carol Bastiani
Paper evidence: Trent C, Tsung N & Horvitz HR, 1983
Treatment: 5 mg/ml serotonin
details
constitutive egg layingAllele:
tr132
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
frequency of body bend variantAllele:
paralyzed arrested elongation two foldlife-stage: elongating embryo Ce, abnormalAllele:
st553
Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.
details
path curvature increasedAllele:
terminal bulb relaxation variantAllele:
n2368
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Delayed relaxation and repolarization of terminal bulb. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed
details
spicules protrude Allele:
tr86
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
tr132
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
backward locomotion variantAllele:
axon termination defectiveanatomy-term: ALM, abnormalAllele:
n2368
Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, we observed overextended ALM axons, where the axon extended past its normal termination point and terminated within the tip of the nose, whereas in wild-type, the axon terminates posterior to the tip of the nose.
details
early eggs laidAllele:
locomotion variantAllele:
ad695
Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995
Remark: Mild locomotion defect.
details
fewer eggs in uteroAllele:
body posture amplitude decreasedAllele:
drug resistantAllele:
tr85
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
muscle cell activity variantanatomy-term: vulval muscle, abnormalAllele:
n2368
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Person evidence: Jonathan Hodgkin
Remark: Animals were myotonic.; Vulval muscles show spontaneous contraction. n2368/+ has a phenotype similar to but weaker than n2368.
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
bloatedAllele:
n582
Curator: Karen Yook
Ease of scoring: Es3 easy to score
Paper evidence: Riddle DL, Blumenthal TE, Meyer BJ & Priess JR, 1997
Remark: moderate bloating; n582/Df more severe phenotypes; easy to score (ES3) in adult, difficult to score (ES2) at other stages
details
drug resistantAllele:
tr72
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
embryonic lethalAllele:
av111
Curator: Chris Grove
Person evidence: Andy Golden
details
spicules protrude Allele:
tr71
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
early eggs laidAllele:
drug resistantAllele:
n582
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence
details
constitutive egg layingAllele:
tr79
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
drug resistantAllele:
tr73
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
embryonic lethalAllele:
st556
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: embryonic lethal, probable null phenotype
details
turning frequency variantAllele:
drug resistantAllele:
tr92
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
dumpyAllele:
spicules protrude Allele:
tr92
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
forward point velocity variantAllele:
spicules protrude Allele:
tr132
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
tr89
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
locomotion variantAllele:
n2368
Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995
Remark: Severe locomotion defect.
details
spicules protrude Allele:
tr73
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
spicules protrude Allele:
tr89
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr93
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: The number of eggs in utero of worms treated with the dihydropyridine (DHP) analog nemadipine, did not significantly differ from in utero numbers of animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
sterileAllele:
tm8983
Curator: Karen Yook
Person evidence: National Bioresource Project c/o Dr. Shohei Mitani
Remark: Classified as lethal OR sterile by the National BioResource Project of Japan.
details
multipolar neuronanatomy-term: ALM, abnormalAllele:
tr134
Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, where a short process extends from the posterior side of the ALM cell body, whereas, in wild-type, a single process extends from the anterior side of the ALM cell body.
details
drug resistantAllele:
tr81
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
constitutive egg layingAllele:
n2368
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
tr140
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
male tail morphology variantAllele:
n2368
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Mab. n2368/+ has a phenotype similar to but weaker than n2368.
details
egg laying defectiveAllele:
n582
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained significantly more eggs in utero than wild-type worms.
Treatment: DMSO control conditions.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence
details
spicules protrude Allele:
tr81
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
dumpyAllele:
n2368
Curator: Gary C. Schindelman; Karen Yook
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995
Person evidence: Jonathan Hodgkin
Remark: Dpy: may be due to body muscles hypercontraction. n2368/+ has a phenotype similar to but weaker than n2368.
details
cell physiology phenotypeAllele:
ad1006
Curator: Karen Yook
Paper evidence: Stout RF & Parpura V, 2011
Remark: When measuring Ca2+ excitability of CEPsh cells in response to high extracellular potassium (HiK+), worms did not have changes to the proportion of non-responders when compared to control cells originating from the background strain. | In cells of egl-19 mutants, the Cat. 2 responses had a reduced preponderance when compared to the background. | Cultured CEPsh glial cells from mutant worms exhibit altered intracellular calcium-based responses to depolarization.
details
drug resistantAllele:
tr90
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
constitutive egg layingAllele:
tr69
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
embryonic lethalAllele:
st576
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: embryonic lethal, probable null phenotype
details
drug resistantAllele:
tr76
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
paralyzed arrested elongation two foldlife-stage: elongating embryo Ce, abnormalAllele:
st556
Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Person evidence: Jonathan Hodgkin
Remark: severe Pat, probable null phenotype; Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.
details
spicules protrude Allele:
tr79
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
flaccidAllele:
constitutive egg layingAllele:
ad695
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
ad1006
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence
details
dead eggs laidAllele:
n2368
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Eggs of less than 10 nuclei are laid. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed
details
coiling frequency variantAllele:
paralyzed arrested elongation two foldlife-stage: elongating embryo Ce, abnormalAllele:
st576
Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Person evidence: Jonathan Hodgkin
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.; severe Pat, probable null phenotype
details
shortAllele:
tr81
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
details
drug resistantAllele:
tr137
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
paralyzed arrested elongation two foldlife-stage: elongating embryo Ce, abnormalAllele:
st577
Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Person evidence: Jonathan Hodgkin
Remark: Pat.; Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.; severe Pat, probable null phenotype
details
head bend angle variantAllele:
drug resistantAllele:
tr134
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
tail bend angle variantAllele:
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
ad1006
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained less eggs after treatment with the dihydropyridine (DHP) analog nemadipine compared to animals treated with DMSO alone; wild-type worms retained more eggs after treatment with the DHP anaolog.
Treatment: 5uM nemadipine in DMSO or DMSO alone
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr86
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: The number of eggs in utero of worms treated with the dihydropyridine (DHP) analog nemadipine, did not significantly differ from in utero numbers of animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
terminal bulb contraction variantAllele:
ad695
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Terminal bulb stays contracted for longer than normal, sometimes > 1 sec. Corpus action is normal. Muscle hyperactivated, sticky pumping, short, ad695/+ similar but with weaker phenotypes.
Semi dominant: Person_evidence; Curator_confirmed
details
spicules protrude Allele:
tr74
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
axon termination defectiveanatomy-term: ALM, abnormalAllele:
tr134
Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, we observed overextended ALM axons, where the axon extended past its normal termination point and terminated within the tip of the nose, whereas in wild-type, the axon terminates posterior to the tip of the nose.
details
drug resistantAllele:
tr138
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
egg laying defectiveAllele:
ad1006
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained significantly more eggs in utero than wild-type worms.
Treatment: DMSO control conditions.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence
details
bag of wormsAllele:
n582
details
fewer eggs in uteroAllele:
drug resistantAllele:
tr71
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr135
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
nose movement variantAllele:
anus morphology variantlife-stage: adult male Ce, abnormalAllele:
ad695
Curator: Jolene S. Fernandes
Paper evidence: Avery L, 1993
Remark: Adult males have a blocked anus
Semi dominant: Curator_confirmed; Paper_evidence
details
drug resistantAllele:
tr86
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
paralyzed arrested elongation two foldlife-stage: elongating embryo Ce, abnormalAllele:
st569
Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.
details
constitutive egg layingAllele:
tr71
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
lethalAllele:
tm8983
Curator: Karen Yook
Person evidence: National Bioresource Project c/o Dr. Shohei Mitani
Remark: Classified as lethal OR sterile by the National BioResource Project of Japan.
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
n582
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained less eggs after treatment with dihydropyridine (DHP) analog nemadipine compared to animals treated with DMSO alone; wild-type worms retained more eggs after treatment with the DHP anaolog.
Treatment: 5uM nemadipine in DMSO or DMSO alone
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence
details
spicules protrude Allele:
n2368
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Person evidence: Jonathan Hodgkin
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.; Protruding spicules. n2368/+ has a phenotype similar to but weaker than n2368.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
n2368
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
flaccidAllele:
tak5
Curator: Kenneth R. Norman
Person evidence: Kenneth R. Norman
details
drug resistantAllele:
tr91
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
ad695
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
egg laying variantAllele:
n2368
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Egl. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed
details
egg laying variantgo-term: oviposition, abnormalAllele:
tr74
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained slightly more eggs in utero compared to wild-type animals under the same conditions.
Treatment: DMSO control conditions.
details
spicules protrude Allele:
ad695
Affected by molecule: nemadipine-A
Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Avery L, 1993; Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.; Adult males have protruding spicules
Semi dominant: Curator_confirmed; Paper_evidence
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
tr88
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr136
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr78
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr87
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
body posture wavelength decreasedAllele:
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr81
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: The number of eggs in utero of worms treated with the dihydropyridine (DHP) analog nemadipine, did not significantly differ from in utero numbers of animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
constitutive egg layingAllele:
tr76
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
embryonic lethalAllele:
st577
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: embryonic lethal, probable null phenotype
details
spicule insertion defective Allele:
ad1006
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males could not protrude their spicules.
Treatment: DMSO control conditions.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
tr93
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
drug resistantAllele:
tr69
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
spicules protrude Allele:
tr69
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
drug resistantAllele:
tr70
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
details
male mating defectivelife-stage: adult male Ce, abnormalAllele:
ad695
Curator: Jolene S. Fernandes
Paper evidence: Avery L, 1993
Semi dominant: Curator_confirmed; Paper_evidence
details
spicules protrude Allele:
tr93
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
longAllele:
eating variantAllele:
ad695
Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Weak Eat. ad695/+ similar but with weaker phenotypes.
Semi dominant: Person_evidence; Curator_confirmed
details
constitutive egg layingAllele:
tr73
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
details
amplitude of sinusoidal movement variantAllele:
pausing variantAllele:
paralyzed arrested elongation two foldlife-stage: elongating embryo Ce, abnormalAllele:
st571
Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.
details
muscle dystrophyRNAi:
WBRNAi00064260
Genotype: dys-1(cx-18); hlh-1(cc561)
Paper evidence: Mariol MC & Segalat L, 2001
Remark: The reduction of egl-19 by RNAi greatly reduces the muscle degeneration seen in dys-1(cx-18); hlh-1(cc561) animals.
details
egg laying variantRNAi:
WBRNAi00008534
Paper evidence: Kamath RS et al., 2003
details
body wall muscle sarcomere morphology variantanatomy-term: body wall muscle cell, abnormalRNAi:
WBRNAi00090077
Genotype: jIs01 [myo-3::GFP], translational fusion
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011
Remark: RNAi was observed to significantly perturb myofibril/sarcomere morphology in body wall muscles, as determined by observation of a MYO-3::GFP translational fusion reporter. This affect was observed after chronic RNAi exposure (RNAi continuously for two generations), as well as after acute exposure to RNAi only during adulthood.
details
protruding vulvaRNAi:
WBRNAi00024850
Genotype: NL4256 rrf-3(pk1426)
Paper evidence: Simmer F et al., 2003
details
egg laying defectiveRNAi:
chemotaxis variantRNAi:
WBRNAi00113903
Genotype: ixEx232[gcy-7p::gfp; unc-122p::gfp]; ixEx234[gcy-7p::egl-19(RNAi); gcy-7p::gfp(RNAi); lin-44p::mRFP].
Paper evidence: Shindou T et al., 2019
details
sterile progenyRNAi:
WBRNAi00024850
Genotype: NL4256 rrf-3(pk1426)
Paper evidence: Simmer F et al., 2003
details
clearRNAi:
WBRNAi00008534
Paper evidence: Kamath RS et al., 2003
details

Phenotype not observed:
The following phenotypes have been reported as NOT observed in egl-19
Phenotype Entities Affected Supporting Evidence
body length variantAllele:
tr89
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were approximately wild-type in length.
Treatment: DMSO control conditions.
details
loss of asymmetry ASEAllele:
ad695
Curator: Jolene S. Fernandes
Paper evidence: Chang S, Johnston RJ & Hobert O, 2003
Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters)
details
protein degradation variantAllele:
ad695
Curator: Chris Grove
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011
Remark: Table S2
details
body wall muscle myosin organization defectivelife-stage: elongating embryo Ce, abnormalAllele:
st556
Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: mhcA is partially organized into A-bands.
Treatment: antibody staining with anti-mhcA
details
fat content variantAllele:
ad1015
Curator: Jolene S. Fernandes
Paper evidence: Srinivasan S et al., 2008
Remark: Mutants had wild-type fat content
Treatment: Fat content was visualized by Nile red staining
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
ad695
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
serotonin induced fat reduction variantAllele:
ad1015
Curator: Jolene S. Fernandes
Paper evidence: Srinivasan S et al., 2008
Remark: Mutants were susceptible to the fat-reducing effects of exogenously administered serotonin
Treatment: Reduced fat content of 5-HT-treated animals was visualized by Nile red staining and confirmed by thin-layer chromatography (TLC) quantitation of total triglycerides extracted from vehicle- and 5-HT-treated worms and by Sudan black fat staining
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr79
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr73
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
pumping absentlife-stage: elongating embryo Ce, abnormalAllele:
st577
Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Pharyngeal pumping movements were observed in mutants.
details
body wall muscle actin organization defectivelife-stage: elongating embryo Ce, abnormalAllele:
st569
Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Well organized actin staining pattern.
Treatment: antibody staining with anti-actin
details
pumping absentlife-stage: elongating embryo Ce, abnormalAllele:
st571
Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Pharyngeal pumping movements were observed in mutants.
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr92
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
egg laying response to drug variantAllele:
n2368
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr76
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
protein degradation variantAllele:
n582
Curator: Chris Grove
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011
Remark: Table S2
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr132
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr71
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr69
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
egg laying response to drug variantgo-term: oviposition, abnormalAllele:
tr89
Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained more eggs after treatment with dihydropyridine (DHP) analog nemadipine, compared to control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone
details
egg laying imipramine resistantAllele:
n582
Curator: Carol Bastiani
Paper evidence: Trent C, Tsung N & Horvitz HR, 1983
Remark: Animals respond only weakly to imipramine.
Treatment: 0.75 mg/ml imipramine
details
exploded through vulvaRNAi:
organism morphology variantRNAi:
organism morphology variantRNAi:
WBRNAi00042705
Paper evidence: Sonnichsen B et al., 2005
details
protruding vulvaRNAi:
mitochondria morphology variantanatomy-term: body wall muscle cell, abnormalRNAi:
WBRNAi00090235
Genotype: ccIs4251 [Pmyo-3::MitGFP, Pmyo-3::NLS::GFP-lacZ]
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011
details
locomotion variantRNAi:
rollerRNAi:
sterileRNAi:
lethalRNAi:
maternal sterileRNAi:
WBRNAi00042705
Paper evidence: Sonnichsen B et al., 2005
details
maternal sterileRNAi:
nematode phenotypeRNAi:
dumpyRNAi:
growth rate variantRNAi:
nematode phenotypeRNAi:
WBRNAi00042705
Paper evidence: Sonnichsen B et al., 2005
details
protein degradation variantRNAi:
WBRNAi00089917
Genotype: ccIs55 [unc-54::lacZ]
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011
details
embryonic lethalRNAi:
organism morphology variantRNAi:
embryonic lethalRNAi:
WBRNAi00042705
Paper evidence: Sonnichsen B et al., 2005
details

Interaction-based phenotypes:

The following phenotypes are indirectly caused or affected by some perturbation of egl-19 in the context of a genetic interaction :


Overexpression:
Overexpression of the egl-19 gene results in the following phenotypes.