Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Recessive:
Remark: recessive Pat

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Ease of scoring: Es3 easy to score
Person evidence: Jonathan Hodgkin
Remark: Eat. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook; Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013; Kwok TC et al., 2008
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals continued to retain eggs after treatment with the dihydropyridine (DHP) analog nemadipine compared with control animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone

Curator: Jolene S. Fernandes
Paper evidence: Avery L, 1993
Semi dominant: Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, where a short process extends from the posterior side of the ALM cell body, whereas, in wild-type, a single process extends from the anterior side of the ALM cell body.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Carol Bastiani
Paper evidence: Trent C, Tsung N & Horvitz HR, 1983

Curator: Carol Bastiani
Paper evidence: Trent C, Tsung N & Horvitz HR, 1983
Treatment: 5 mg/ml serotonin

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Delayed relaxation and repolarization of terminal bulb. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, we observed overextended ALM axons, where the axon extended past its normal termination point and terminated within the tip of the nose, whereas in wild-type, the axon terminates posterior to the tip of the nose.

Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995

Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995
Remark: Mild locomotion defect.

Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Person evidence: Jonathan Hodgkin
Remark: Animals were myotonic.; Vulval muscles show spontaneous contraction. n2368/+ has a phenotype similar to but weaker than n2368.
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Ease of scoring: Es3 easy to score
Paper evidence: Riddle DL, Blumenthal TE, Meyer BJ & Priess JR, 1997
Remark: moderate bloating; n582/Df more severe phenotypes; easy to score (ES3) in adult, difficult to score (ES2) at other stages

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Chris Grove
Person evidence: Andy Golden

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: embryonic lethal, probable null phenotype

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Gary C. Schindelman; Jolene S. Fernandes
Paper evidence: Avery L, 1993; Reiner DJ, Weinshenker DZ & Thomas JH, 1995
Remark: Slightly dumpy
Semi dominant: Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995
Remark: Severe locomotion defect.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: The number of eggs in utero of worms treated with the dihydropyridine (DHP) analog nemadipine, did not significantly differ from in utero numbers of animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone

Curator: Karen Yook
Person evidence: National Bioresource Project c/o Dr. Shohei Mitani
Remark: Classified as lethal OR sterile by the National BioResource Project of Japan.

Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, where a short process extends from the posterior side of the ALM cell body, whereas, in wild-type, a single process extends from the anterior side of the ALM cell body.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Mab. n2368/+ has a phenotype similar to but weaker than n2368.

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained significantly more eggs in utero than wild-type worms.
Treatment: DMSO control conditions.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Gary C. Schindelman; Karen Yook
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995
Person evidence: Jonathan Hodgkin
Remark: Dpy: may be due to body muscles hypercontraction. n2368/+ has a phenotype similar to but weaker than n2368.

Curator: Karen Yook
Paper evidence: Stout RF & Parpura V, 2011
Remark: When measuring Ca2+ excitability of CEPsh cells in response to high extracellular potassium (HiK+), worms did not have changes to the proportion of non-responders when compared to control cells originating from the background strain. | In cells of egl-19 mutants, the Cat. 2 responses had a reduced preponderance when compared to the background. | Cultured CEPsh glial cells from mutant worms exhibit altered intracellular calcium-based responses to depolarization.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: embryonic lethal, probable null phenotype

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Person evidence: Jonathan Hodgkin
Remark: severe Pat, probable null phenotype; Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook; Carol Bastiani
Paper evidence: Trent C, Tsung N & Horvitz HR, 1983; Kwok TC et al., 2008
Remark: floppy
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Eggs of less than 10 nuclei are laid. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Person evidence: Jonathan Hodgkin
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.; severe Pat, probable null phenotype

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Person evidence: Jonathan Hodgkin
Remark: Pat.; Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.; severe Pat, probable null phenotype

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained less eggs after treatment with the dihydropyridine (DHP) analog nemadipine compared to animals treated with DMSO alone; wild-type worms retained more eggs after treatment with the DHP anaolog.
Treatment: 5uM nemadipine in DMSO or DMSO alone
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: The number of eggs in utero of worms treated with the dihydropyridine (DHP) analog nemadipine, did not significantly differ from in utero numbers of animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Terminal bulb stays contracted for longer than normal, sometimes > 1 sec. Corpus action is normal. Muscle hyperactivated, sticky pumping, short, ad695/+ similar but with weaker phenotypes.
Semi dominant: Person_evidence; Curator_confirmed

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Buddell, Tyler & Quinn, Christopher C, 2021
Remark: In egl-19(gof) mutants, we observed overextended ALM axons, where the axon extended past its normal termination point and terminated within the tip of the nose, whereas in wild-type, the axon terminates posterior to the tip of the nose.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained significantly more eggs in utero than wild-type worms.
Treatment: DMSO control conditions.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Carol Bastiani
Paper evidence: Trent C, Tsung N & Horvitz HR, 1983

Curator: Gary C. Schindelman
Paper evidence: Reiner DJ, Weinshenker DZ & Thomas JH, 1995

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Jolene S. Fernandes
Paper evidence: Avery L, 1993
Remark: Adult males have a blocked anus
Semi dominant: Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Curator: Karen Yook
Person evidence: National Bioresource Project c/o Dr. Shohei Mitani
Remark: Classified as lethal OR sterile by the National BioResource Project of Japan.

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained less eggs after treatment with dihydropyridine (DHP) analog nemadipine compared to animals treated with DMSO alone; wild-type worms retained more eggs after treatment with the DHP anaolog.
Treatment: 5uM nemadipine in DMSO or DMSO alone
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Person evidence: Jonathan Hodgkin
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.; Protruding spicules. n2368/+ has a phenotype similar to but weaker than n2368.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Kenneth R. Norman
Person evidence: Kenneth R. Norman

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Egl. n2368/+ has a phenotype similar to but weaker than n2368.
Semi dominant: Person_evidence; Curator_confirmed

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained slightly more eggs in utero compared to wild-type animals under the same conditions.
Treatment: DMSO control conditions.

Affected by molecule: nemadipine-A
Curator: Karen Yook; Jolene S. Fernandes
Paper evidence: Avery L, 1993; Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.; Adult males have protruding spicules
Semi dominant: Curator_confirmed; Paper_evidence
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Affected by molecule: nemadipine-A
Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: The number of eggs in utero of worms treated with the dihydropyridine (DHP) analog nemadipine, did not significantly differ from in utero numbers of animals treated with DMSO alone.
Treatment: 5uM nemadipine in DMSO or DMSO alone

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: embryonic lethal, probable null phenotype

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males could not protrude their spicules.
Treatment: DMSO control conditions.
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog.
Treatment: Animals were treated with various concentrations of nemadipine in DMSO.

Curator: Jolene S. Fernandes
Paper evidence: Avery L, 1993
Semi dominant: Curator_confirmed; Paper_evidence

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Males had protruded spicules (Prc). The Prc phenotype was suppressed by nemadipine.
Treatment: nemadipine
Variation effect: Hypermorph gain of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook; Carol Bastiani
Paper evidence: Trent C, Tsung N & Horvitz HR, 1983; Kwok TC et al., 2008
Variation effect: Hypomorph reduction of function; Curator_confirmed; Paper_evidence

Curator: Karen Yook
Person evidence: Jonathan Hodgkin
Remark: Weak Eat. ad695/+ similar but with weaker phenotypes.
Semi dominant: Person_evidence; Curator_confirmed

Curator: Karen Yook
Paper evidence: Kwok TC et al., 2008
Remark: Animals retained fewer embryos in utero than wild-type.
Treatment: DMSO control conditions

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Chris Grove
Paper evidence: Yemini E, Jucikas T, Grundy LJ, Brown AE & Schafer WR, 2013

Curator: Jolene S. Fernandes
Paper evidence: Williams BD & Waterston RH, 1994
Remark: Severe Pat phenotype: Embryos are paralyzed at the 1.5-fold stage.

Genotype: dys-1(cx-18); hlh-1(cc561)
Paper evidence: Mariol MC & Segalat L, 2001
Remark: The reduction of egl-19 by RNAi greatly reduces the muscle degeneration seen in dys-1(cx-18); hlh-1(cc561) animals.

Paper evidence: Kamath RS et al., 2003

Genotype: jIs01 [myo-3::GFP], translational fusion
Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011
Remark: RNAi was observed to significantly perturb myofibril/sarcomere morphology in body wall muscles, as determined by observation of a MYO-3::GFP translational fusion reporter. This affect was observed after chronic RNAi exposure (RNAi continuously for two generations), as well as after acute exposure to RNAi only during adulthood.

Genotype: NL4256 rrf-3(pk1426)
Paper evidence: Simmer F et al., 2003

Paper evidence: Shephard F, Adenle AA, Jacobson LA & Szewczyk NJ, 2011

Genotype: ixEx232[gcy-7p::gfp; unc-122p::gfp]; ixEx234[gcy-7p::egl-19(RNAi); gcy-7p::gfp(RNAi); lin-44p::mRFP].
Paper evidence: Shindou T et al., 2019

Genotype: NL4256 rrf-3(pk1426)
Paper evidence: Simmer F et al., 2003

Paper evidence: Kamath RS et al., 2003