The expression levels of T04D3.1 reporter was dramatically increased and more protein aggregates were formed in lgg-1(RNAi) animals than in wild-type animals.
"C. elegans Src homology 3 (SH3) domain interactome was mapped using stringent yeast two hybrid, resulting in a total of 1070 interactions among 79 out of 84 worm SH3 domains and 475 proteins."