kars-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable lysine-tRNA ligase activity and tRNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode larval development; and regulation of brood size. Predicted to be located in cytosol and mitochondrion. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Expressed in tail. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Is an ortholog of human KARS1 (lysyl-tRNA synthetase 1).