unc-116 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables plus-end-directed microtubule motor activity. Involved in several processes, including establishment of organelle localization; organelle organization; and positive regulation of cell projection organization. Located in several cellular components, including neuron projection; nuclear envelope; and synapse. Part of kinesin I complex. Expressed in several structures, including AVA; body ganglion; muscle cell; tail; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; asbestos-related lung carcinoma; autoimmune disease (multiple); and complex cortical dysplasia with other brain malformations 2. Is an ortholog of human KIF5A (kinesin family member 5A); KIF5B (kinesin family member 5B); and KIF5C (kinesin family member 5C).