This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion morphogenesis. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Expressed in several structures, including body wall musculature; excretory canal; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate carcinoma in situ; and sporadic breast cancer. Is an ortholog of human PHB1 (prohibitin 1).
Predicted to enable protein homodimerization activity. Involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion organization. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Expressed in body wall musculature; excretory canal; hypodermis; intestine; and neurons. Is an ortholog of human PHB2 (prohibitin 2).
Predicted to be located in membrane. Is an ortholog of C. elegans phb-2. In C. elegans, phb-2 is involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion organization.
Predicted to be located in membrane. Is an ortholog of C. elegans phb-2. In C. elegans, phb-2 is involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion organization.
Predicted to be located in membrane. Is an ortholog of C. elegans phb-2. In C. elegans, phb-2 is involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion organization.
Predicted to be located in membrane. Is an ortholog of C. elegans phb-1. In C. elegans, phb-1 is involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion morphogenesis.
Predicted to be located in membrane. Is an ortholog of C. elegans phb-2. In C. elegans, phb-2 is involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion organization.