gene: tpa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mitogen-activated protein kinase kinase kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to other organism; positive regulation of antimicrobial peptide production; and positive regulation of axon regeneration. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 3; fatty liver disease; and portal hypertension. Is an ortholog of human PRKCD (protein kinase C delta) and PRKCQ (protein kinase C theta).